Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off

Van Parijs, L., & Abbas, A. K. (1998). Homeostasis and self-tolerance in the immune system: turning lymphocytes off. Science280(5361), 243-248.


The immune system responds in a regulated fashion to microbes and eliminates them, but it does not respond to self-antigens. Several regulatory mechanisms function to terminate responses to foreign antigens, returning the immune system to a basal state after the antigen has been cleared, and to maintain unresponsiveness, or tolerance, to self-antigens. Here, recent advances in understanding of the molecular bases and physiologic roles of the mechanisms of immune homeostasis are examined.

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